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Ernst E, Pittler MH: Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. Padma-Nathan H: Fildena citrate (Fildena) and erectile dysfunction: a comprehensive four year update on efficacy, safety, and management options. Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF: Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat.

Plante GE: Vascular response to stress in health and disease. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F, D'Armiento M, Giugliano D: Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. Nicolosi A, Glasser DB, Moreira ED, Villa M: Prevalence of erectile dysfunction and associated factors among men without concomitant diseaes: a population study.

Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB: Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Levine LA, Kloner RA: Importance of asking questions about erectile dysfunction. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R: Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration.

Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A: The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Calles-Escandon J, Cipolla M: Diabetes and endothelial dysfunction: a clinical perspective. Fink HA, Mac DR, Rutks IR, Nelson DB, Wilt TJ: Fildena for male erectile dysfunction: a systematic review and meta-analysis.

Kaiser FE: Erectile dysfunction in the aging man. Feldiabetesan HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Romeo JH, Seftel AD, Madhun ZT, Aron DC: Sexual function in men with diabetes type 2: association with glycemic control.

Tina K. Thethi, MD, is a fellow in Endocrinology, Metabolism, and Diabetes; Nana Asafu-Adjaye, MPH, is the clinical research coordinator for the ACCORD Trial; and Vivian A. Fonseca, MD, is the Tullis Tulane Alumni Chair in Diabetes and chief of the Section of Endocrinology and Metabolism at Tulane University Health Sciences Center in New Orleans, La. Diabetes research and education at Tulane University Health Sciences Center is supported in part by the John C. Cudd Memorial Fund, the Tullis-Tulane Alumni Chair in Diabetes, and the Susan Harling Robinson Fellowship in Diabetes Research. Comprehensive evaluation and treatment of ED can lead to overall improved quality of life and well being for patients.

Patients with ED should undergo evaluation of cardiovascular risk factors and assessment for subclinical CVD on a routine basis. Follow-up at regular intervals and reassessment of all patients receiving treatment for ED is highly recommended.
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